Pathogenesis of immunoglobulin G4-related hepatobiliary disease
10.3760/cma.j.issn.1007-3418.2018.06.019
- VernacularTitle: 免疫球蛋白G4相关肝胆疾病的发病机制
- Author:
Bingyuan HUANG
1
;
Qixia WANG
;
Xiong MA
Author Information
1. Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai 200001, China
- Publication Type:Review
- Keywords:
Hepatitis, autoimmune;
Immunoglobulin G4-related sclerosing cholangitis;
Genetics;
B lymphocytes;
T lymphocytes;
Pathogenesis
- From:
Chinese Journal of Hepatology
2018;26(6):472-475
- CountryChina
- Language:Chinese
-
Abstract:
IgG4-relaed hepatobiliary diseases (IgG4-HBD) are the hepatobiliary manifestations of IgG4-related disease, a multisystem fibro-inflammatory disorder. Previous studies on the pathogenesis of genetics and immunology have provided significant assistance in understanding the disease, rational diagnosis and treatment, but there are still many unknowns and challenges. The current research progress summarizes several factors influencing fibrosis and inflammation in the pathogenesis of disease.
