A Case of Group O Losing Anti-B Selectively.
- Author:
Seon Ho LEE
1
;
Joseph JEONG
;
Ui Suk JEONG
;
Jai Ho WEE
;
Tae Woo KIM
;
Jeong Hwan BAI
;
Geum Sook KANG
;
Sung Ryul KIM
;
Seog Woon KWON
Author Information
1. Department of Laboratory Medicine, Ulsan University Hospital, Ulsan, Korea. srkimuuh@hitel.net
- Publication Type:Case Report ; Evaluation Studies
- Keywords:
Group O losing anti-B;
ABO discrepancy;
Hypogammaglobulinemia
- MeSH:
Adult;
Agammaglobulinemia;
Alleles;
Exons;
Humans;
Lymphocytes;
Male;
Polymerase Chain Reaction;
Sequence Analysis, DNA;
Tissue Donors
- From:Korean Journal of Blood Transfusion
2007;18(3):244-248
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of group O losing anti-B selectively. A 25-year-old male donated blood; on the donor test an ABO discrepancy was noted, and a further evaluation study was performed. ABO genotyping with an allele specific polymerase chain reaction assay revealed O/O and DNA sequencing of exons 6 and 7 of the ABO gene showed O01/O02. The serum gammaglobulin level was decreased and only 0.2% CD19 pan-B positive lymphocytes were present in a subset of lymphocytes. In a previous donor study, anti-B of the patient was lost from a third donor study and was still not detected.
