Research progress in membrane fusion process among Paramyxoviruses
10.3760/cma.j.issn.1003-9279.2018.06.021
- VernacularTitle: 副粘病毒膜融合机制的研究进展
- Author:
Miaomiao CHI
1
;
Zhiyu WANG
Author Information
1. Department of Virology, School of Public Health, Shandong University, Jinan 250012, China
- Publication Type:Review
- Keywords:
Paramyxoviruses;
HN/G/H proteins;
F protein;
Membrane fusion
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(6):654-658
- CountryChina
- Language:Chinese
-
Abstract:
The family Paramyxoviridae is a group of viruses that significantly affect human and animal health. Paramyxoviruses are generally thought to enter host cells by direct fusion of the viral and host cell membranes. Membrane fusion, essential for syncytium formation, is not only a pathological hallmark of paramyxoviral infections, but also a kind of mechanism of cell-to-cell viral spread. Nevertheless, the process of membrane fusion is highly conserved, only consisting of two-component fusion apparatus: an attachment protein (HN/G/H) and a fusion (F) protein. However, there is a significant knowledge gap on the mechanism(s) by which HN/H/G couples receptor binding to F-triggering, since different attachment proteins possess special triggering process. In this review, we summarize the general property and distinction of the fusion process during paramyxoviral infection for further research on the pathogenic mechanism.
