Clinical features and molecular characteristics of influenza A (H1N1) viral pneumonia in 17 elderly patients
10.3760/cma.j.issn.1003-9279.2018.06.004
- VernacularTitle: 17例病毒性肺炎老年患者的临床特点及甲型H1N1流感病毒分子特征
- Author:
Yiyue GE
1
;
Yan TAN
2
;
Chen CHEN
2
;
Tao WU
1
;
Xiaojuan ZHU
1
;
Kangchen ZHAO
1
;
Li WANG
2
;
Wei GU
2
;
Lunbiao CUI
1
Author Information
1. Key Laboratories of Enteric Pathogenic Microbiology of Ministry of Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China
2. Department of Respiratory Diseases, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210009, China
- Publication Type:Journal Article
- Keywords:
Elderly;
Influenza A (H1N1);
Pneumonia;
Clinical features;
Molecular characteristics
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(6):576-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical manifestations and results of etiological examinations of 17 elderly patients with influenza A (H1N1) viral pneumonia, and to understand the clinical features of pneumonia and molecular characteristics of influenza A (H1N1) virus infection in the elderly.
Methods:The elderly patients with pneumonia who were hospitalized in the Department of Respiratory Diseases of Nanjing First Hospital from January 2018 to March were enrolled. The cases were confirmed by nucleic acid examination for influenza virus and the clinical data were collected. After the amplification of the whole genome of influenza virus, the high throughput sequencing and bioinformatics analysis were performed.
Results:The mean age of the 17 enrolled patients was 73.8±10.8. All of them had at least 1 underlying disease, and 7 cases had co-infection. Respiratory symptoms and fever were the most prominent clinical manifestations. Lesions in both lungs were found in 76.5% of the patients. The result of high throughput sequencing showed that all the viruses were highly homologous to the vaccine strain, and the HA gene belonged to the 6B.1 subgroup. Furthermore, three variations of antigenic locus (H138Y, S74R and S164T in HA) and a drug-resistant variation (H275Y in NA) were detected in the circulating strains.
Conclusions:Elderly patients with influenza A (H1N1) virus pneumonia often have underlying diseases and are prone to have co-infection. The molecular characteristics of the virus and the variation of key amino acid loci should be closely monitored in order to provide evidence for epidemic prevention and clinical antiviral treatment.
