Plasma Exchange in a Patient with Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
- Author:
Yun Soo LEE
1
;
Jung Ran PARK
;
Kyu Sub SONG
;
Yong Lim KIM
;
Jang Soo SUH
Author Information
1. Department of Laboratory Medicine, Kyungpook National University Hospital, Daegu, Korea. suhjs@knu.ac.kr
- Publication Type:Case Report
- Keywords:
ANCA;
Vasculitis;
Plasma exchange
- MeSH:
Antibodies, Antineutrophil Cytoplasmic;
Autoimmune Diseases;
Cyclophosphamide;
Cytapheresis;
Cytoplasm*;
Female;
Glomerulonephritis;
Hemorrhage;
Humans;
Immunoglobulins;
Immunosuppressive Agents;
Middle Aged;
Peroxidase;
Plasma Exchange*;
Plasma*;
Prognosis;
Tumor Necrosis Factor-alpha;
Vasculitis*
- From:Korean Journal of Blood Transfusion
2007;18(3):254-259
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a systemic autoimmune disease with a poor prognosis in untreated patients, and combination therapy with steroidsand cyclophosphamide is the current standard treatment. Treatment with immunosuppressive agents results in high remission rates; however, there is a considerable morbidity related to the immunosuppressive state, such as life-threatening infections. To reduce serious immunosuppressant-related adverse effects, potentially promising treatment options, including plasma exchange, cytapheresis, administration of intravenous immunoglobulin and TNF-alpha blocking agents have been developed. We performed plasma exchange with steroid pulse therapy for a 52 year-old female patient with pulmonary hemorrhagewith ANCA-associated crescentic glomerulonephritis. After combination therapy, the pulmonary hemorrhage and renal function recovered and myeloperoxidase (MPO)-ANCA decreased.
