A Case of Effective Post-centrifugal Plasma Filtration for L-asparaginase-induced Severe Hyperlipidemia.
- Author:
Jae Woo CHUNG
1
;
Seog Woon KWON
;
Yusun MIN
;
Young A KIM
;
Ho Joon IM
;
Seon Ho LEE
Author Information
1. Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Hypertriglyceridemia;
L-asparaginase;
Plasmapheresis;
Plasma filtration
- MeSH:
Ambulatory Care Facilities;
Child;
Cholesterol;
Filtration*;
Humans;
Hyperlipidemias*;
Hypertriglyceridemia;
Lipoproteins;
Pancreatitis;
Plasma*;
Plasmapheresis;
Triglycerides
- From:Korean Journal of Blood Transfusion
2007;18(3):269-274
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyperlipidemia has been reported in children with acute lymphoblastic leukemiawho have been treated with L-asparaginase alone or in combination with a steroid. Hyperlipidemia caused by L-asparaginase is usuallyreversible after drug discontinuation, and is rarely associated with severe complications. However, the risk of acute pancreatitis is increased if there is a large increase in triglyceride levels. Prompt correction of hyperlipidemia should be considered to prevent this severe complication. We report a case of successful correction of L-asparaginase-associated severe relapsed hyperlipidemia using post-centrifugal plasma filtration (PCPF), a type of selective plasmapheresis. After 3 sessions of PCPF, the serum concentrations of lipids were markedly reduced. The serum concentration for triglyceridewas reduced to 475 mg/dL from 6,298 mg/dL, the total cholesterol level was reduced to 176 mg/dL from 946 mg/dL, and the level of low-density lipoprotein was reduced to 4 mg/dL from 403 mg/dL. One month later, as determined at the outpatient clinic, the lipid levels were normalized. PCPF was effective for clearing severely increased plasma lipids.
