Progress of targeting inhibition of Sonic Hedgehog signaling pathway in leukemia
10.3760/cma.j.issn.1006-9801.2018.05.016
- VernacularTitle: 靶向抑制Sonic Hedgehog信号通路在白血病中的研究进展
- Author:
Lulu CHEN
1
;
Fanping WANG
Author Information
1. School of Laboratory Medicine, Xinxiang Medical University, Molecular Diagnosis and Laboratory Medicine Collaborative Innovation Center in Henan Province, Xinxiang 453003, China
- Publication Type:Review
- Keywords:
Sonic Hedgehog signaling pathway;
Leukemia;
Targeted therapy
- From:
Journal of Leukemia & Lymphoma
2018;27(5):311-315
- CountryChina
- Language:Chinese
-
Abstract:
Sonic Hedgehog (SHH) signaling pathway participates in the regulation of various organs and growth of tissue cells, maintains normal function and structure in the development of embryogenesis, however, SHH signaling pathway is in a state of inhibition. Meanwhile, the abnormal regulation of SHH signaling pathway plays an important role in the occurrence, development and drug resistance of leukemia. The mechanism of SHH signaling pathway in leukemia is similar to the solid tumor. With the further understanding of SHH signaling pathway, there are many antitumor drugs targeting SHH signaling pathway. The targeting inhibitors targeted SHH signaling pathway will become a new method for the treatment of leukemia. This paper reviews the application of the inhibitors targeting SHH signaling pathway in leukemia.
