Acute myeloid leukemia combined with myeloid sarcoma: report of three cases and review of literature
10.3760/cma.j.issn.1009-9921.2018.05.007
- VernacularTitle: 急性髓系白血病合并髓系肉瘤三例并文献复习
- Author:
Zhanyun LIU
1
;
Jie HAO
1
;
Zhenyu LIU
1
;
Yu CHEN
2
;
Qiusheng CHEN
2
;
Junmin LI
2
Author Information
1. Department of Hematology, Shanghai Beizhan Hospital, Department of Hematology Medical Conjoined in Ruijin Hospital, Shanghai 200070, China
2. Department of Hematology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Hematology, Shanghai 200025, China
- Publication Type:Journal Article
- Keywords:
Leukemia, myeloid, acute;
Myeloid sarcoma;
Treatment outcome
- From:
Journal of Leukemia & Lymphoma
2018;27(5):285-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the diagnosis and treatment of acute myeloid leukemia (AML) complicated with myeloid sarcoma (MS).
Methods:The clinical features, diagnosis and therapy of 3 AML who were treated with routine regimen induction and consolidation therapy in Shanghai Beizhan Hospital and showed MS during the marrow remission stage were retrospectively analyzed.
Results:Three female patients included 2 cases of CBFβ-MYH11 positive and 1 case of AML1-ETO positive. One patient occurred in the first complete remission(CR1) and 2 patients occurred in CR2. The involved sites included brain, vagina, and breast respectively. Three patients all received short efficacy after chemotherapy, including 1 patient in bone marrow remission stage, 1 patient died of after bone marrow relapse and 1 patient without follow-up.
Conclusions:For AML patients in remission with extramedullary lesions, pathological examination is warranted to confirm the diagnosis of the disease. Systemic chemotherapy is still the main treatment for MS. Central nervous system(CNS) leukemia treatment should be performed to the patients with CNS involved. Allogeneic hematopoietic stem cell transplantation may be the best option for the treatment of these patients.
