Chronic myeloid leukemia with blast phase as initial manifestation: report of three cases and analysis of laboratory characteristics
10.3760/cma.j.issn.1009-9921.2018.05.006
- VernacularTitle: 以急变期为首发的慢性粒细胞白血病三例临床及实验室特征分析
- Author:
Huirui WANG
1
;
Shuli GUO
;
Bo LI
;
Wanli WANG
;
Songyun WANG
Author Information
1. Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang 471009, China
- Publication Type:Journal Article
- Keywords:
Leukemia, myeloid, acute;
Leukemia, myeloid, chronic;
Philadelphia chromosome;
Blast phase
- From:
Journal of Leukemia & Lymphoma
2018;27(5):280-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical and laboratory features of chronic myeloid leukemia(CML) patients with blast phase as initial presentation.
Methods:The clinical manifestation, laboratory bindings and treatment of 3 CML patients with blast phase as the initial presentation from January 2015 to November 2016 in Luoyang Central Hospital Affiliated to Zhengzhou University were analyzed. The first symptoms of 3 patients were similar to acute leukemia.
Results:The patients were presented with splenomegaly, obvious rise of white blood cell count in peripheral blood, increasing number of initial cells in the bone marrow, Philadelphia chromosome-positive (Ph+), fluorescence in situ hybridization of bcr-abl1 with fusion signals in segmented granulocytes, fusion gene with p210 positive and without the typical chronic phase of CML.
Conclusions:Due to the increased number of marrow blasts and the similarity of clinical manifestations to acute leukemia in CML patients with blast phase as the initial presentation, it is easy to misdiagnose as Ph+ acute leukemia in the initial phase. While some differences in genetics, clinical manifestations and genomics between them may help in differential diagnosis.
