The impact of male circumcision on the natural history of genital HPV infection: a prospective cohort study
10.3760/cma.j.issn.0253-9024.2018.05.007
- VernacularTitle: 男性包皮环切对外生殖器HPV感染自然史影响的前瞻性研究
- Author:
Feixue WEI
1
;
Meng GUO
;
Xinjing MA
;
Yue HUANG
;
Ya ZHENG
;
Lin WANG
;
Yan SUN
;
Sijie ZHUANG
;
Kai YIN
;
Yingying SU
;
Shoujie HUANG
;
Mingqiang LI
;
Ting WU
;
Jun ZHANG
Author Information
1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China
- Publication Type:Journal Article
- Keywords:
Circumcision, male;
Cohort studies;
Human papillomavirus;
Incidence;
Clearance
- From:
Chinese Journal of Preventive Medicine
2018;52(5):486-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between circumcision and incidence and clearance of male genital HPV infection.
Methods:From May to July 2014, 18-55 year old men who had sexual behavior history were recruited from the general population in Liuzhou, Guangxi to set up a cohort. Totally, 113 circumcised and 560 uncircumcised men were enrolled and interviewed using a questionnaire (including information on demographic characteristics and sexual behaviors), then they were followed-up with 6-month interval for 2 times. On each visit, specimens of male external genitalia were collected and genotyped for HPV DNA. The differences of incidence and clearance of genital HPV infections between circumcised and uncircumcised men were analyzed by Log-rank test. Cox regression was used to analyze the relationship between circumcision and incidence and clearance of HPV infection.
Results:The median age (P25, P75) of circumcised and uncircumcised men were 28 (24, 35) and 32 (24, 31), respectively. The incidences of any HPV infections were 9.1 (95%CI: 2.4-15.7) and 8.4 (95% CI: 5.6-11.2) per 1 000 person-months (χ2=0.10, P=0.758), respectively. The clearance of circumcised men [136.3 (95%CI: 70.0-202.7) per 1 000 person-months] was higher than that in uncircumcised men [89.6 (95%CI: 65.9-113.3) per 1 000 person-months] (χ2=8.19, P=0.004). In multivariate COX regression analysis, compared with uncircumcised men, circumcised men had higher possibility to clear any HPV infections (HR: 2.41, 95%CI: 1.30-4.46). Compared with men having one sexual partner, people having more than 4 sexual partners had lower possibility to clear any HPV infections (HR: 0.49, 95%CI: 0.25-0.96). Compared with 18-25 years old men, men aged 26-35 years old had higher possibility to clear high-risk HPV infections (HR: 2.14, 95%CI: 1.08-4.23).
Conclusion:Circumcised and uncircumcised men had similar incidence of genital HPV infection, whereas, men conducted circumcision and having fewer sexual partners could increase the clearance of genital HPV infections.
