Role of HPV viral loads in random biopsy under normal colposcopy
10.3760/cma.j.issn.0253-9624.2018.05.005
- VernacularTitle: HPV载量在阴道镜下随机活检中的作用分析
- Author:
Xiaoqian XU
1
;
Li ZHANG
;
Shangying HU
;
Remila REZHAKE
;
Xuelian ZHAO
;
Feng CHEN
;
Xun ZHANG
;
Qinjing PAN
;
Youlin QIAO
;
Fanghui ZHAO
Author Information
1. Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Journal Article
- Keywords:
Cervical Intraepithelial Neoplasia;
Human papillomavirus;
Random biopsy;
Directed biopsy
- From:
Chinese Journal of Preventive Medicine
2018;52(5):475-479
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of HPV viral loads in random biopsy under normal colposcopy.
Methods:908 atypical squamous cells of undetermined significance (ASC-US) and HPV positive women, recruited in cluster sampling in 9 provinces including 5 urban areas and 9 rural areas in China from 1999 to 2008 and meeting the inclusion and exclusion criteria were included in this analysis. According to relative light units/cutoff (RLU/CO) value, subjects were stratified as low (286 cases), intermediate (311 cases) and high (311 cases) viral load groups. Risks of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among different viral load groups were compared with linear trend Chi-square test.
Results:Detection rate of CIN3+ in low, intermediate and high viral load groups were 2.1% (6 cases), 2.6% (8 cases) and 6.8% (21 cases) (Chi-square test for trend χ2=8.91, P=0.003) and were 60.3, 74.0 and 201.3 times higher than ASC-US and HPV negative women, respectively. Among 908 subjects, 27.0% (245 cases) were abnormal under colposcopy and 68.6% (623 cases) diagnosed as normal. Under normal colposcopy, detection rate of CIN3+ in low, intermediate and high viral load groups were 0.9% (2 cases), 0.9% (2 cases) and 3.8% (7 cases) (χ2=6.42, P=0.040).
Conclusion:HPV viral loads display satisfactory risk stratification ability among ASC-US and HPV positive women under normal colposcopy. Women with high HPV viral loads show a significantly increased detection rate of existing CIN3+ and could be recommended to perform random biopsy for histologic diagnosis.
