Progress of long non-coding RNA in regulating cell autophagy in cancer
10.3760/cma.j.issn.0253-3766.2018.05.001
- VernacularTitle: 长链非编码RNA调控肿瘤细胞自噬的研究进展
- Author:
Wenwen LIU
1
;
Xianjuan SHEN
1
;
Shaoqing JU
1
Author Information
1. Department of Clinical Laboratory, Affiliated Hospital of Nantong University, Nantong 226001, China
- Publication Type:Review
- Keywords:
Long non-coding RNA;
Autophagy;
Neoplasms
- From:
Chinese Journal of Oncology
2018;40(5):321-324
- CountryChina
- Language:Chinese
-
Abstract:
The initiation of tumor is a complex process with multi-factor participation, particularly the activation of oncogenes and/or inactivation of tumor suppressor genes. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis. Additionally, as a metabolic process in cells, autophagy also contributes greatly to differentiation, metastasis and chemoresistance of tumor cells, and has become a central topic in recent years. The understanding of connection between lncRNAs and autophagy as well as their mechanisms underlying tumorigenesis, can provide new ideas for the diagnosis and treatment of tumors.
