Key signal molecules of wingless-related integration pathway and targeted therapy for liver cancer
10.3760/cma.j.issn.1007-3418.2018.05.017
- VernacularTitle: Wnt通路关键信号分子与肝癌靶向治疗
- Author:
Wenjie ZHENG
1
;
Dengfu YAO
Author Information
1. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China
- Publication Type:Review
- Keywords:
Carcinoma, hepatocellular;
Diagnosis;
Prognosis;
Wnt pathway;
Molecular target
- From:
Chinese Journal of Hepatology
2018;26(5):397-400
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is one of the most common digestive system tumors. Its occurrence and development are considered as multi-factorial and multi-step process. Recent studies have shown that wingless-related integration (Wnt) pathway plays an important role in the HCC progression and is associated with malignant transformation of hepatocytes, HCC metastasis, drug resistance and liver cancer stem cells. This article analyzes the expression of key signaling molecules in Wnt pathway and its value in diagnosis, prognosis and targeted therapy, and outlines the research progress of Wnt pathway targeted drugs for the treatment of HCC, with a view to providing targeted therapy research for HCC reference.
