Clinical analysis of de novo HBV infection after liver transplantation in non-HBV- related liver disease
10.3760/cma.j.issn.1007-3418.2018.05.012
- VernacularTitle: 非HBV相关性肝病肝移植术后新发HBV感染的临床分析
- Author:
Bacui ZHANG
1
;
Hong CHEN
;
Zhongyang SHEN
;
Xu WANG
;
Tieyan FAN
;
Jun LI
;
Qing ZHANG
;
Xinguo CHEN
;
Li LI
;
Jun LI
;
Yujian NIU
Author Information
1. Institute of Organ Transplantation, the General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Liver diseases;
Hepatitis B virus;
Infection
- From:
Chinese Journal of Hepatology
2018;26(5):377-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The aim of this study was to summarize and analyze the clinical features and characteristics of de novo HBV infection after liver transplantation in non-HBV-related liver disease.
Methods:We retrospectively analyzed the clinical data of 13 patients with new HBV infection in 376 cases of liver transplantation patients with non-HBV related liver diseases from April 2002 to December 2013 in our hospital.
Results:Among 376 patients with non-HBV-related liver disease after liver transplantation, 13 patients developed new HBV infection, and the rate of new HBV infection was 3.46%. Of the 13 cases, 5 were males and 8 were females. The follow-up time was 14.7 -128.7 months, and the average time from surgery to new HBV infection was 19.06 months. The primary diseases were as follows: 5 cases of primary biliary cholangitis, 3 cases of alcoholic liver disease, 2 cases of drug-induced liver damage, 1 cases of post-hepatitis C cirrhosis, congenital biliary atresia and congenital liver fibrosis. All patients were positive for HBsAg, HBeAg, anti-HBc, 11 were positive for HBV DNA, and 2 were negative for HBV DNA. 6 cases had abnormal liver function and 7 cases had normal liver function. All patients were treated with antiviral therapy with nucleoside (acid) analogues. HBsAg was negative in 6 patients; HBsAg remained positive in 7 cases, including HBsAg, HBeAg, anti-HBc positive in 6 cases, HBsAg, anti-HBe, anti- HBc was positive in 1 case, HBV DNA was still positive in 1 patient, and HBV DNA was negative in 6 patients; liver function was normal in all patients.
Conclusion:Non-HBV- related liver transplantation are high-risk group of new HBV infection, with the highest incidence of autoimmune liver disease. It is speculated that it may be related to the long-term use of hormones after the transplantation. The prognosis of newly diagnosed HBV infection after liver transplantation is fine as long as it can be found and treated early.
