Clinical and laboratory characteristics of chronic neutrophilic leukemia: analyses of five cases
10.3760/cma.j.issn.1009-9921.2018.04.010
- VernacularTitle: 慢性中性粒细胞白血病五例临床及实验室特征分析
- Author:
Sufen GUO
1
;
Yan HUANG
;
Jianlan LI
;
Bo YANG
;
Xiuhua CHEN
Author Information
1. Diagnosis Laboratory, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Journal Article
- Keywords:
Leukemia, myeloid, chronic-phase;
Cellular morphology;
Genes;
Receptors, colony-stimulating factor;
Janus kinase 2
- From:
Journal of Leukemia & Lymphoma
2018;27(4):234-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics, cell morphology, genetics, gene mutations of the patients with chronic neutrophilic leukemia (CNL).
Methods:Five CNL patients from the Second Hospital of Shanxi Medical University between May 2011 and May 2017 who conformed to 2016 World Health Organization (WHO) diagnostic criteria were retrospectively analyzed from clinical characteristics, laboratory features and treatment methods.
Results:The peripheral blood white blood cell count (WBC) of 5 CNL patients was significantly increased, and the average WBC was 81.26×109/L [(29-217)×109/L]. Morphological analysis of peripheral blood cell showed a sustained increasing number of matured neutrophilia (0.80-0.85). Neutrophil alkaline phosphatase (NAP) activity was increased (144-266). Bone marrow cell morphology typically showed granulocyte proliferation without obvious dysplasia. Gene detection showed 3 patients with CSF3R T618I mutation and 2 patients with JAK2 V617F mutation in 5 WHO-defined CNL patients. Bone marrow biopsy with reticular staining showed that marrow fibrosis (MF) degree in patients with JAK2 V617F mutation (MF≥2) was higher than that in patients with CSF3R T618I mutation(MF<2).
Conclusions:CNL is a rare type of chronic leukemia, and CSF3R T618I mutation is a specific diagnostic index for CNL. JAK2 V617F mutations alone may be related to myelofibrosis, which remains to be further studied.
