Biological characteristics and treatment progress of splenic and nodal marginal zone lymphoma in indolent lymphoma

VernacularTitle: 脾和淋巴结边缘区惰性淋巴瘤生物学特征及治疗研究进展
Author: Yiwen ZHANG ¹ ; Jun HOU ; Jumei SHI
Author Information

1. Department of Hematology, Shanghai Tenth People's Hospital, the Affiliated Tenth People's Hospital of Tongji University, Tongji University Cancer Center, Shanghai 200072, China
Publication Type:Review
Keywords: Lymphoma, B-cell, marginal zone; Splenic marginal zone lymphoma; Nodal marginal zone lymphoma; Individualized medicine
From: Journal of Leukemia & Lymphoma 2018;27(4):201-205,211
CountryChina
Language:Chinese
Abstract: Splenic marginal zone lymphoma (SMZL) and nodal marginal zone lymphoma (NMZL) are rare indolent chronic B-cell lymphomas. Clinical research has made a great progress thanks to the developments of genomic studies and a large number of overlapping mutational profiles involving NOTCH, BCR and nuclear factor κB (NF-κB) signaling, chromatin remodeling, and the cytoskeleton. This paper reviews the recent progress of biological characteristics and treatment progress of SMZL and NMZL in indolent lymphoma combined with the 59th American Society of Hematology (ASH) Annual Meeting.