Comprehensive geriatric assessment can predict the clinical outcomes of elderly patients with diffuse large B cell lymphoma in China
10.3760/cma.j.issn.0253-2727.2018.04.002
- VernacularTitle: 综合性老年评估体系对中国老年弥漫大B细胞淋巴瘤患者的预后价值
- Author:
Chunli ZHANG
1
;
Ru FENG
;
Jiangtao LI
;
Yuan TIAN
;
Ting WANG
;
Hui LIU
Author Information
1. Department of Hematology, Beijing Hospital, Beijing 100730, China
- Publication Type:Journal Article
- Keywords:
Lymphoma, large B-cell, diffuse;
Antineoplastic combined chemotherapy protocols;
Comprehensive geriatric assessment
- From:
Chinese Journal of Hematology
2018;39(4):271-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To validate comprehensive geriatric assessment (CGA) system in Chinese elderly diffuse large B cell lymphoma (DLBCL) patients.
Methods:Patients ≥ 65 years of age who had been diagnosed with de novo DLBCL were screened for eligibility (n=99). CGA was performed during staging procedures through application of the following instruments: age, comorbidity score according to the Cumulative Illness Rating Score for Geriatrics(CIRS-G), activities of daily living (ADL), and instrumental activities of daily living (IADL).
Results:All patients were classified as "ft" , "unfit" , and "frail" . Forty-nine (49.5%), 14 (14.1%), and 34 (36.4%) patients were categorized into the fit, unfit, and frail groups, respectively. The overall response rate was 91.8%, 64.3%, and 69.5% in fit, unfit, and frail group, respectively (χ2=9.311, P=0.007). Eleven (22.4%), 7 (50.0%), and 16(44.4%) patients showed disease relapse/progression in fit, unfit, and frail group, respectively (χ2=6.309, P=0.040). The 2-year probability of overall survival was 90.6%, 43.0%, and 58.5% in fit, unfit, and frail group, respectively (χ2=14.774, P=0.001). The 2-year probability of progression-free survival was 72.9%, 32.5%, and 37.3% in fit, unfit, and frail group, respectively (χ2=11.038, P=0.004).
Conclusion:The CGA index can predict the clinical outcomes of elderly DLBCL patients in China.
