Getting to zero mother-to-child transmission of hepatitis B virus: dream and challenge
10.3760/cma.j.issn.1007-3418.2018.04.006
- VernacularTitle: 乙型肝炎病毒母婴零传播：理想与挑战
- Author:
Xueru YIN
1
;
Zhihua LIU
1
;
Zhihong LIU
1
;
Jie LI
2
;
Hui ZHUANG
2
;
Xiaoguang DOU
3
;
Jinlin HOU
1
Author Information
1. Institute of Hepatology, Southern Medical University, Guangzhou 510515, China
2. Department of Microbiology & Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China
3. Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, 110022, China
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatitis B vaccines;
Mother-to-child transmission;
Hepatitis B immunoglobulin
- From:
Chinese Journal of Hepatology
2018;26(4):262-265
- CountryChina
- Language:Chinese
-
Abstract:
To eliminate viral hepatitis as a public health threat, the World Health Organization has set the ambitious goal of reducing the prevalence of hepatitis B surface antigen (HBsAg) in children to 0.1% by 2030, and the key to this grand goal is cutting off hepatitis B virus (HBV) transmission from mother-to-child. Previously, national and international guidelines for the management of chronic hepatitis B recommended the use of hepatitis B vaccine and hepatitis B immunoglobulin (HBIG) or combination of any in neonates and antiviral drugs for pregnant women with high viral load in late pregnancy. However, a recent study in Thailand found that the addition of antiviral drugs in pregnant women with high viral load in the third trimester did not significantly lower the incidence of mother-to-child HBV transmission, but no case of chronic HBV infection was seen with strict standards hepatitis B vaccine and HBIG combined immunoprophylaxis and the use of tenofovir disoproxil in pregnant women with high viral load in the third trimester. In addition, the incidence of mother –to- child transmission of HBV in the antiviral group was 0, while the incidence of HBV transmission in the placebo group was 2%. Therefore, it is not possible to deny the efficacy of adding antiviral drugs in treating pregnant women with high viral load in the third trimester with combined immunoprophylaxis. There is an urgent need for more real-world studies in clinical practice to further reveal the principles and existing problems of mother- to- child transmission of HBV.
