Advances in the research of effects of glutamine on immune function of burn patients
10.3760/cma.j.issn.1009-2587.2018.04.012
- VernacularTitle: 谷氨酰胺对烧伤患者免疫功能影响的研究进展
- Author:
Yanhua LIU
1
;
Pengfei GUO
;
Gaiyun CHEN
;
Yacong BO
;
Yan MA
;
Zhengjun CUI
Author Information
1. Department of Nutrition, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
- Publication Type:Review
- Keywords:
Burns;
Glutamine;
Immunity;
Intestinal tract
- From:
Chinese Journal of Burns
2018;34(4):249-253
- CountryChina
- Language:Chinese
-
Abstract:
Glutamine is the most abundant amino acid found in plasma and cells. It is the preferred fuel for enterocytes in the small intestine, macrophages, and lymphocytes. After serious burn, increased requirement of glutamine by the gastrointestinal tract, kidney and lymphocytes, and relatively insufficient self synthesis likely contribute to the rapid decline of glutamine in circulation and cells. Glutamine supplementation can not only protect intestinal mucosa, maintain normal intestinal barrier function, reduce bacterial translocation, and enhance the intestinal immune function, but also increase the number of lymphocytes, enhance the phagocytic function of macrophage, promote the synthesis of immunoglobulin, and reduce the body′s inflammatory response, so as to enhance the immune function. Therefore, glutamine supplementation can improve and enhance the immune function, reduce complications and promote the prognosis of severely burned patients.
