Evolution of rabies vaccination regimen
10.3760/cma.j.issn.1003-9279.2018.04.024
- VernacularTitle: 狂犬病疫苗免疫程序的演变
- Author:
Chuanlin WANG
1
Author Information
1. Emergency Department, Peking University People’s Hospital, Beijing 100044, China
- Publication Type:Review
- Keywords:
Rabies vaccine;
Vaccination procedure;
Intradermal injection;
Intramuscular injection
- From:Chinese Journal of Experimental and Clinical Virology
2018;32(4):440-444
- CountryChina
- Language:Chinese
-
Abstract:
Rabies vaccine has gradually evolved from the birth of nerve tissue vaccine to cell vaccine, and vaccination time has been simplified from the initial implementation of 14-21 needles to current 4-5 needles. Four types of vaccination procedures are recommended by WHO for rabies pre and post-exposure prophylaxis: two types of intradermal (ID) multipoint injection and two types of intramuscular (IM) injection. The most commonly used vaccination procedures are the 5-dose regimen (" 1-1-1-1-1" regimen i. e. Essen regimen) and 4-dose regimen (" 2-1-1" regimen i. e. Zagreb regimen). Vaccination according to the above vaccination procedures recommended by WHO could effectively prevent human rabies. The vaccination procedures of rabies vaccine approved in China are Essen regimen and Zagreb regimen.
