Effects of human immunodeficiency virus-1 Tat protein on blood brain barrier and its mechanism
10.3760/cma.j.issn.1003-9279.2018.04.020
- VernacularTitle: HIV-1 Tat蛋白对血脑屏障的作用及其分子机制
- Author:
Wenhui ZHENG
1
;
Li ZHAO
Author Information
1. Department of Laboratory Science of Sanitary Microbiology, School of Public Health, Shandong University, Jinan 250012, China
- Publication Type:Review
- Keywords:
Human immunodeficiency virus-1;
Tat protein;
Blood brain barrier;
Mechanism
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(4):422-425
- CountryChina
- Language:Chinese
-
Abstract:
Human immunodeficiency virus-1 (HIV-1) infects the human body and acts on the related cells of blood brain barrier, causing structural and functional abnormalities of blood brain barrier, which will be beneficial to the invasion of the virus into central nervous system. There are many types of the molecular mechanism of damage of blood brain barrier. Tat protein, as HIV-1 trans-activator of transcription, can damage the vascular endothelial cells, pericytes and astrocytes, and reduce the tight junction protein expression. Some chemicals such as methamphetamine can cooperate with HIV-1 Tat protein damage blood brain barrier. In this paper, the effects and its mechanism of HIV-1 Tat protein on blood brain barrier are reviewed.
