Molecular mechanism of pyroptosis and its role in viral infections
10.3760/cma.j.issn.1003-9279.2018.04.019
- VernacularTitle: 细胞焦亡的分子机制及其在病毒感染中的作用
- Author:
Kegong ZHANG
1
;
Jian WANG
;
Ye ZHANG
;
Changxing HUANG
Author Information
1. Department of Infectious Diseases, the Second Affiliated Hospital of Air Force Medical Univerisity, Xi′an 710038, China
- Publication Type:Review
- Keywords:
Pyroptosis;
Inflammasome;
Caspase-1/11;
Gasdermin-D
- From:Chinese Journal of Experimental and Clinical Virology
2018;32(4):418-421
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a newly discovered form of programmed cell death, and morphologically, it has the characteristics of both necrosis and apoptosis. Gasdermin-D is the executive protein in pyroptosis. Pyroptosis-related caspases were activated in cells after stimulation, and then caspases hydrolyzed to gasdermin-D.Subsequently, gasdermin-N domain combined to cytomembrane to form membrane pores. The pores disrupt the osmotic potential and cause cell swelling and eventual lysis. The process was also accompanied by releasing of inflammatory cytokines. This review focused on the morphology, molecular mechanism of pyroptosis and its role in viral infections.
