Association between Helicobacter pylori infection and overweight/obesity among adult health checkup population in China
10.3760/cma.j.issn.1674-0815.2018.04.008
- VernacularTitle: 体检人群幽门螺杆菌感染与超重、肥胖的相关性研究
- Author:
Zhengce WAN
1
;
Liu HU
1
;
Mei HU
1
;
Xiaomei LEI
1
;
Yuancheng HUANG
1
;
Yongman LYU
1
Author Information
1. Physical Examination Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Overweight;
Obesity
- From:
Chinese Journal of Health Management
2018;12(4):327-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between Helicobacter pylori (H. pylori) infection and overweight/obesity in a Chinese population.
Methods:This was a cross-sectional study that included all adult participants who underwent a 13C-urea breath test at the physical examination center in Tongji Hospital (Wuhan, China) in 2016. Data on demographic characteristics, anthropometric index, biochemical variables, and medical history were collected. Multivariate analyses were performed to assess the relationship between H. pylori infection and overweight/obesity, as well as body mass index (BMI).
Results:Of the 27 883 participants included, 17 585 were males and 10 298 were females. They were aged (43.94±11.31) years. The prevalence rate of H. pylori infection was 33.1%. The BMIs of subjects with and without H. pylori infection were (24.30±3.28) kg/m2 and (23.99±3.35) kg/m2, respectively (t=-7.28, P<0.001). After adjusting for age, sex, blood lipid levels, diabetes, and hypertension, the BMI of subjects with H. pylori infection was 0.120 kg/m2 (95% CI: 0.050-0.191, P=0.001), which was higher than that of subjects without H. pylori infection. Moreover, H. pylori infection was independently associated with a higher risk of prevalent overweight/obesity, with an odds ratio (OR) of 1.09 (95%CI: 1.03-1.16, P=0.004). The positive association between H. pylori infection and overweight/obesity was more evident among women, with an OR of 1.19 (95%CI: 1.07-1.31, P=0.001).
Conclusion:H. pylori infection was closely correlated with overweight/obesity. Control of H. pylori infection may be useful in reducing the heavy disease burden caused by overweight/obesity.
