Application value of real-time three-dimensional contrast-enhanced ultrasound for morphological assessing of hepatocellular carcinoma before radiofrequency ablation treatment
10.3760/cma.j.issn.0253-3766.2018.03.012
- VernacularTitle: 实时三维超声造影在肝癌射频消融术前病灶形态学评估中的应用价值
- Author:
Xianchen WANG
1
;
Shiyan LI
2
;
Yong FANG
3
;
Ling ZHOU
1
;
Lilong XU
2
;
Yao WU
1
Author Information
1. Department of Ultrasound, Hangzhou Xiasha Hospital, Xiasha Campus of Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310018, China
2. Department of Ultrasound, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310016, China
3. Department of Oncology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310016, China
- Publication Type:Clinical Trail
- Keywords:
Liver neoplasms;
Contrast-enhanced ultrasound;
Three-dimensional imaging;
Radiofrequency ablation
- From:
Chinese Journal of Oncology
2018;40(3):217-221
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the evaluating ability of real-time three-dimensional contrast-enhanced ultrasound (RT-3D-CEUS) for morphology of hepatocellular carcinoma (HCC) before radiofrequency ablation (RFA) treatment.
Methods:Sixty patients with 88 targeted lesions were enroll in this study, who have received RFA in Hangzhou Xiasha Hospital. The pretreatment imaging data of CEUS and RT-3D-CEUS were retrospective analysis. Morphological features were assessed according to the size and shape of the lesions, and were compared between two modalities with the post-treatment response as the reference standard.
Results:The size of lesion measured by CEUS and RT-3D-CEUS was similar in 70 out of 88 lesions (group A). In the other 18 lesions, the size measured by RT-3D-CEUS was larger than that by CEUS (group B). For the shape analysis, 38 lesions were spheroid by CEUS and 34 lesions by RT-3D-CEUS; 47 lesions were oval by CEUS and 41 lesions by RT-3D-CEUS; 3 lesions were irregular by CEUS and 13 lesions by RT-3D-CEUS. There were 78 lesions which shape assessed by two modalities consistently (group A′), and the other 10 lesions with inconsistent shape by two modalities (group B′). Three months follow-up results showed that 4 lesions appeared tumor residue (5.7%) in group A′ and 6 lesions (33.3%) in group B′. There was significant difference between these two groups (P=0.004). In the group A′, there were 6 lesions (7.7%) showed tumor residue, and 4 lesions (40.0%) in group B′. The difference between these two groups was also significant (P=0.012).
Conclusion:RT-3D-CEUS could be used to assess the size and shape of HCC accurately which is associated with the response of RFA.
