Extensive peritumoral retraction clefts and prognosis in invasive breast carcinomas of no specific type
10.3760/cma.j.issn.0529-5807.2018.03.010
- VernacularTitle: 非特殊型浸润性乳腺癌中大范围癌周间隙的出现对预后的影响
- Author:
Huiyan DENG
1
;
Xinran WANG
;
Meng YUE
;
Lingling ZHANG
;
Fang LI
;
Xiaoling WANG
;
Yueping LIU
Author Information
1. Department of Pathology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Lymphatic metastasis;
Prognosis
- From:
Chinese Journal of Pathology
2018;47(3):196-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of extensive retraction clefts (RC, >20% of tumor volume) on prognosis in invasive breast carcinoma of no specific type (IBC-NST).
Methods:A total of 2 184 cases of IBC-NST diagnosed at the Fourth Hospital of Hebei Medical University from January 2006 to December 2008 were collected. All the cases were diagnosed according to the latest guideline and standard. After excluding cases of shrinkage due to tissue fixation, 483 cases with RC were identified, and the clinical and pathological features were retrospectively analyzed.
Results:Among the 483 cases, the mean tumor size was 2.0 cm (range 0.8 to 4.8 cm). Two hundred and thirty-two cases were moderately differentiated (48.0%), 97 were well differentiated (20.1%), 154 were poorly differentiated (31.9%); 382 (79.1%) cases were of stages Ⅰ and Ⅱ. A total of 177 cases (36.7%) had lymphatic invasion; nodal metastasis were found in 202 cases (41.8%). Extensive RC was found in 237 of 483 cases (49.1%). Follow-up information was available in 407 patients, and 46 died of breast cancer with survival time from 37 to 103 months. Multivariate analysis of extensive RC showed that tumor size, histological grade and nodal metastasis were risk factors of patients with IBC-NST (P<0.05). Lymphatic invasion and nodal metastasis were risk factors for extensive RCs in patients with IBC-NST (P<0.05). There was a high probability of lymph node metastasis in patients of extensive RC without lymphatic invasion, and the difference was statistically significant (P<0.05).
Conclusions:Both lymphatic invasion and nodal metastasis are risk factors of extensive RC. The presence of extensive RC in IBC-NST patients is correlated with poor outcome. Tumors with lymphatic invasion are more likely to show extensive RC.
