Correlation between C-MYC protein expression and genetic abnormalities in diffuse large B-cell lymphoma
10.3760/cma.j.issn.0529-5807.2018.03.005
- VernacularTitle: 弥漫性大B细胞淋巴瘤中C－MYC蛋白表达与基因异常的相关性
- Author:
Hai YU
1
;
Hui WANG
;
Na ZHANG
;
Sumei GAO
;
Yunxiang ZHANG
Author Information
1. Department of Pathology, Weifang Medical University, Shandong Province, Weifang 261053, China
- Publication Type:Journal Article
- Keywords:
Lymphoma, large B-cell, diffuse;
Proto-oncogene proteins c-myc;
Gene amplification
- From:
Chinese Journal of Pathology
2018;47(3):172-175
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation between expression of oncogene C-MYC protein and gene abnormality in diffuse large B-cell lymphoma (DLBCL).
Methods:The expression of C-MYC protein and gene abnormality were detected by immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, in 42 cases of paraffin-embedded DLBCL. All cases were collected at Department of Pathology, Weifang People′s Hospital during January 2015 to October 2016.
Results:The positive rate of C-MYC protein expression was 47.6% (20/42) and the rate of abnormal C-MYC gene by FISH was 26.2%(11/42), including translocation (23.8%, 10/42) and gene amplification (2.4%, 1/42). There was a close relationship between the protein expression and gene translocation (χ2=11.813; P=0.001) and gene translocation occurred primarily in GCB (χ2=4.029; P=0.045).
Conclusion:The high expression (≥40%) of C-MYC protein is associated with its gene translocation, suggesting that C-MYC protein detection can be used as a surrogate marker for C-MYC gene translocation in DLBCL.
