Association of human rhinovirus infection with asthma in children
10.3760/cma.j.issn.1003-9279.2018.03.026
- VernacularTitle: 人鼻病毒感染与儿童哮喘的关系研究进展
- Author:
Xiaohe ZHOU
1
;
Linqing ZHAO
Author Information
1. Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China
- Publication Type:Review
- Keywords:
Children;
Asthma;
Human rhinovirus
- From:Chinese Journal of Experimental and Clinical Virology
2018;32(3):333-337
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a serious global health problem affecting all age groups. It has been recognized as a complex disease resulting from interactions between multiple genetic and environmental factors. Human rhinovirus (HRV) infections in early life constitute a major environmental risk factor for the development of childhood asthma and the most common cause of asthma exacerbation. HRV-C, the novel HRV, using cadherin-related family member 3 (CDHR3) as receptors, plays a key role in the development of childhood asthma. This review discusses the role and the potential underlying mechanisms of HRV infections in the development and exacerbation of childhood asthma based on recent clinical and experimental evidence.
