Research progress in antiviral effects of SERINC family proteins
10.3760/cma.j.issn.1003-9279.2018.03.025
- VernacularTitle: SERINC家族蛋白抗病毒作用的研究进展
- Author:
Huimin XIAO
1
;
Yue LIU
2
;
Wenyan ZHANG
1
Author Information
1. Institute of AIDS and Virus, Bethune First Hospital, Jilin University, Changchun 130012, China
2. Department of Cardiology and Ultrasound, First Hospital, Jilin University, Changchun 130012, China
- Publication Type:Review
- Keywords:
Serine incorporator (SERINC);
Human immunodeficiency virus (HIV);
Anti-virus
- From:Chinese Journal of Experimental and Clinical Virology
2018;32(3):328-332
- CountryChina
- Language:Chinese
-
Abstract:
Serine incorporator (SERINC) is a multi-transmembrane family of carrier proteins that is highly conserved among species and helps to integrate serine into lipid bilayers to efficiently synthesize phospholipids Phosphatidylserine and sphingolipids. Recent studies have found that SERINC protein family, especially SERINC3 and SERINC5, act on many different viruses, such as human immunodeficiency virus (HIV) which causes AIDS, inhibit the replication and proliferation of the virus to achieve antiviral effects. The study on the mechanism of virus-host cell interaction has been a hot spot in the field and has important scientific significance. In this article, the structural features of SERINC protein family, the major biological functions, and the interaction with the virus in the anti-virus process are summarized in order to provide important information for the research on the host-virus interaction.
