Investigation on the effects of booster immunization of human diploid cell rabies vaccine after eight years of primary vaccination
10.3760/cma.j.issn.1003-9279.2018.03.003
- VernacularTitle: 人二倍体细胞狂犬病疫苗免疫8年后加强免疫效果研究
- Author:
Jiahong ZHU
1
;
Xiaohong WU
2
;
Yuhua LI
2
;
Fengcai ZHU
3
;
Yuemei HU
3
Author Information
1. Center for Disease Prevention and Control of Lianshui Country, Lianshui 223400, China
2. Division of Arboviral Vaccine, National Institutes for Food and Drug Control, Beijing 100050, China
3. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China
- Publication Type:Journal Article
- Keywords:
Rabies;
Human diploid cell rabies vaccine (HDCV);
Rapid fluorescent focus inhibition test (RFFIT);
Neutralizing antibody
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(3):233-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To disclose the effects of booster immunization of human diploid cell rabies vaccine (HDCV) after eight years of primary vaccination.
Methods:Sixty subjects who had participated the phase Ⅲ clinical trial of freeze-dried HDCV were selected and gaven booster immunization after eight years of primary vaccination. The side effects of booster immunization were observed. The serum before and after 14 days of booster immunization were collected and detected the rabies virus neutralizing antibody (RVNA) by rapid fluorescent focus inhibition test (RFFIT). The positive rate and geometric mean titer (GMT) of RVNA before and after booster immunization were made statistical analysis.
Results:Total 54 subjects finished the follow-up and RVNA detection. No sever side-effects were observed in 30 min or 15 days of follow-up after booster immunization. The positive rate of RVNA before and after booster immunization were 51.85% (28/54) and 96.30% (52/54). The GMT of RVNA before and after booster immunization were 1.42 IU/ml and 30.61 IU/ml.
Conclusions:The freeze-dried HDCV has good immune effects with one-dose of booster immunization after eight years of primary vaccination.
