Analysis of the early immune effects of rabies vaccine combined with human rabies immunoglobulin
10.3760/cma.j.issn.1003-9279.2018.03.002
- VernacularTitle: 狂犬病疫苗和人狂犬病免疫球蛋白联合应用早期免疫效果分析
- Author:
Zerong ZHU
1
;
Sha LU
1
;
Zhenggang ZHU
1
;
Man ZHANG
1
;
Yi ZHENG
2
;
Quan HU
2
Author Information
1. Wuhan Centers for Disease Control and Prevention, Wuhan 430015, China
2. Wuhan Institute of Dermatology and Venereology, Wuhan 430032, China
- Publication Type:Journal Article
- Keywords:
Rabies vaccine;
Human rabies immunoglobulin;
Rabies virus neutralizing antibody;
Rapid fluorescent focus inhibition test
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(3):228-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the early immune effects of rabies vaccine combined with human rabies immunoglobulin (HRIG).
Methods:Rapid fluorescent focus inhibition test (RFFIT) was used to test the titers of rabies virus neutralizing antibodies (RVNA). The titers of RVNA of persons who had exposed to rabies at degree III on day 0, day 1, day 7, day 14 and day 45 were compared. The dynamic curves and seroconversion rates (SCR) of RVNA in persons of different genders, age and vaccine regimens (Essen and Zagreb) groups were analyzed.
Results:No significant differences of SCR among different genders, age and vaccine regimens groups were observed on the same day. SCR could be 100% on day14 in different groups. The dynamic curves of RVNA within the first 14 days showed the models of gradual rise, rapid rise and rapid decline.
Conclusions:The dynamic curves of RVNA within the first 14 days varied when rabies vaccines were used in combination with HRIG, and not all subjects were proved to be protected based on the RVNA detection within this period.
