Biomonitoring application in the exposome assessment
10.3760/cma.j.issn.0253-9624.2018.02.017
- VernacularTitle: 生物监测在暴露组评价中的应用
- Author:
Guiping HU
1
;
Zhangjian CHEN
;
Shichuan TANG
;
Guang JIA
Author Information
1. Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
- Publication Type:Review
- Keywords:
Population surveillance;
Environmental exposure;
Biomonitoring;
Exposome;
Combined application
- From:
Chinese Journal of Preventive Medicine
2018;52(2):201-205
- CountryChina
- Language:Chinese
-
Abstract:
Biomonitoring can be applied to assess internal exposure and environmental exposure by exposure markers with providing internal exposure to biological characterization and individual exposure information, which is a key tool to evaluate the risk exposure to disease by biological alternation information. With the development of high throughput, broad spectrum and high efficiency screening and detection technology, biomonitoring is defined as traditional biological monitoring (targeted monitoring) and non targeted monitoring analysis (exposomic approaches). An exposomic approach differs from traditional biomonitoring in that it can theoretically include all exposures of potential health significance, whether they are derived from exogenous sources. Both traditional and nontraditional biomonitoring methods should be used to understand the complexity of exposures faced throughout the lifespan. Through hybrid approaches, emerging techniques and the integration of bioinformatics, and developing the detection methods for low abundance chemicals, improving the differentiation ability between endogenous and exogenous chemical, the health outcomes and exposures can be widely recognized and characterized, which can finally contribute to improving the precise prevention and intervention for diseases under the new exposomic model.
