Effect of postoperative precision nutrition therapy on postoperative recovery for advanced gastric cancer after neoadjuvant chemotherapy
10.3760/cma.j.issn.0253-3766.2018.02.009
- VernacularTitle: 术后精准营养疗法对新辅助化疗后进展期胃癌患者术后恢复的效果观察
- Author:
Qun ZHAO
1
;
Yong LI
1
;
Bin YU
1
;
Peigang YANG
1
;
Liqiao FAN
1
;
Bibo TAN
1
;
Yuan TIAN
1
;
Anbo YANG
1
Author Information
1. The Third Department of Surgery, the Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050011, China
- Publication Type:Clinical Trail
- Keywords:
Nutrition therapy;
Neoadjuvant therapy;
Stomach neoplasms, advanced;
Indirect energy determination
- From:
Chinese Journal of Oncology
2018;40(2):127-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of postoperative precision nutrition therapy on postoperative recovery (PR) of patients with advanced gastric cancer (AGC) after neoadjuvant chemotherapy (NC).
Methods:71 subjects were randomly divided into 2 groups. The 34 patients of research group were treated with postoperative precision nutrition treatment according to the indirect energy measurement method. The 31 patients of control group were treated with traditional postoperative nutrition treatment. All participants were measured for body mass index (BMI), NRS2002, PG-SGA and relevant laboratory test within the 1st day before surgery and 7th day after surgery. Moreover, the difference between two groups in short-term effects were evaluated.
Results:The daily energy supply of control group was 30.1%-43.74% higher than that of the experimental group (P<0.05). The resting energy expenditure (REE) of the research group after surgery was lower than that before operation. The levels of prealbumin, albumin and lymphocyte count were higher in research group than the controls at the 7th day after surgery whereas the opposite was true for the creatinine, urea nitrogen, C-reactive protein and procalcitonin (P<0.05). Similarly, the rate of malnutrition and nutritional risk became lower in the research group (P<0.05). The gastrointestinal function recovery of patients in the research group was comparable to that of the control group (P>0.05). Moreover, the complication rate and hospitalization costs of in research group were significantly lower than that of in control group (P<0.05). For patients with or without nutritional risks before surgery, the nutritional index and inflammatory index in the research group were better than those in the control group.
Conclusion:Postoperative precision nutrition therapy may improve the postoperative nutritional status and short-term effects of patients with AGC after NC.
