Relationship between bile acid metabolism and chronic non - cholestatic liver disease
10.3760/cma.j.issn.1007-3418.2018.02.016
- VernacularTitle: 胆汁酸代谢与慢性非胆汁淤积性肝脏疾病的关系
- Author:
Liting YAN
1
;
Junfeng LI
2
;
Zhongping DUAN
3
;
Qingfeng CHEN
2
Author Information
1. The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
2. Department of Infectious Diseases & Infectious Diseases Institute, the First Hospital of Lanzhou University, Lanzhou 730000, China
3. Center of Artificial Liver, Beijing Youan Hospital, Capital University of Medical Sciences, Beijing 100069, China
- Publication Type:Review
- Keywords:
Cholestasis;
Liver diseases;
Bile acid
- From:
Chinese Journal of Hepatology
2018;26(2):151-154
- CountryChina
- Language:Chinese
-
Abstract:
Bile acid is a general term for a large class of cholic acid in bile and exerts its unique physiological functions by binding the relevant receptors and bile acid transporters. Bile acids not only promote the absorption of nutrients in the human body, but also as an important signaling molecule in the regulation of inflammatory processes and liver regeneration. Several studies have found that bile acid metabolism is involved in the occurrence and development of chronic non-cholestatic liver diseases. In this article, the latest research results are mentioned, and the relationship between nuclear receptors, membrane receptors, and bile acid transporters and chronic non-cholestatic liver disease that play a key role in the bile acid metabolism were emphatically reviewed.