Clinical characteristics of bocavirus infection in children with bronchiolitis
10.3760/cma.j.issn.1003-9279.2018.02.017
- VernacularTitle: 婴幼儿毛细支气管炎中人博卡病毒感染及其临床特征分析
- Author:
Xuan LIANG
1
,
2
;
Rongfang ZHANG
1
;
Zhiping XIE
3
;
Hanchun GAO
3
;
Zhaojun DUAN
3
;
Donghai LIU
1
,
2
Author Information
1. Children′s Asthma Center, Gansu Provincial Maternity and Children Health Care Hospital, Lanzhou, 730050, China
2. Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, China
3. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
- Publication Type:Journal Article
- Keywords:
Human bocavirus;
Bronchiolitis;
Infant;
Infection;
Clinical characteristics
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(2):187-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the human bocavirus (HBoV) infection in the children diagnosed with brochiolitis, incomparison with the clinical characteristics of bronchiolitis of HBoV vs. respiratory syncytial virus (RSV) infection alone.
Methods:A total of 396 throat swabs were obtained from children diagnosed with bronchiolitis from January 2015 to December 2016 in Pediatric Asthma Center of Gansu Maternal and Child Health Care Hospital, Lanzhou. Specimens were tested for the nucleic acids of HBoV, RSV and other 6 common respiratory viruses by nested-polymerase chain reaction (nested PCR() and reverse transcription-polymerase chain reaction (RT-PCR), and the epidemic status, clinical characteristics of HBoV and RSV were analyzed and compared with each other.
Results:The positive rate of virus infection was 53.54%, and HBoV and RSV infections were 9.84% and 24.49% in 396 cases. The numbers of cases of HBoV single infection, RSV single infection, HBoV and RSV mixed infection were 29, 86 and 5. The number of boys infected with HBoV was 27. There was statistical significance in the difference between the genders. The statistical significance also existed in difference of age. The babies at ages ranging from 6 to 12 months had the hifgest positive rate. The first incidence peak of the infection of HBoV was in October 2015. The children with HBoV infection, compared with RSV patients, presented more often with vomiting, diarrhea (P<0.05), while symptoms such as the occurrence of dyspnea, hypoxemia and the hospitalization time were all lower.
Conclusions:HBoV is one of the possible causes of brochiolitis in infants, its infection distributed over the whole year. The clinical symptoms, laboratory and radio-graphic changes are similar between the HBoV and RSV infections, the only difference was that the HBoV infection was comparatively mild.
