Continued circulation and phylogenetic analysis of human adenovirus-55 in China during 2006-2016
10.3760/cma.j.issn.1003-9279.2018.02.004
- VernacularTitle: 新型人腺病毒55型在中国10年的持续流行及其基因进化分析
- Author:
Naiying MAO
1
;
Zhen ZHU
1
;
Zhenqiang LEI
1
;
Yan LI
2
;
Fang HUANG
3
;
Jie YIN
4
;
Meng CHEN
3
;
Xingyu XIANG
5
;
Hong LI
1
;
Liuying TANG
1
;
Aili CUI
1
;
Zhong LI
6
;
Ti LIU
6
;
Wenbo XU
1
Author Information
1. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
2. Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China
3. Beijing Center for Disease Control and Prevention, Beijing 100013, China
4. Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China
5. Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China
6. Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China
- Publication Type:Journal Article
- Keywords:
New adenovirus type 55;
Acute respiratory infection;
Bayesian evolutionary analysis;
Gene
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(2):124-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To better understand the evolution and epidemiology of human adenovirus-55 (HAdV-55) and provide a scientific basis for the prevention and control of the epidemic of HAdV-55 in China.
Methods:HAdV-55 isolates from 5 provinces in China included Beijing, Hebei, Shandong, Hunan and Yunnan were collected during 2011-2014. The hexon, fiber and penton base gene were sequenced, and compared with other strains of HAdV-55 sequences downloaded from GenBank for homology and evolution analysis.
Results:During the past decade, HAdV-55 was found in 15 provinces throughout China. Genetic and phylogenetic analysis showed that the HAdV-55 virus is highly conservative in evolution due to aggregation in a branch in the evolutionary tree. However, bayesian phylogenetic tree shows a certain time evolution trend. The evolution rate of hexon and fiber gene of HAdV-55 are 5.228×10-5 and 1.238×10-4 substitutions/site/year respectively, and the latest coevolutionary ancestor tMRCA of hexon gene can be traced back to 1963.
Conclusions:HAdV-55 has been widely spread and continued circulating in China. Establishing effective monitoring system and conducting vaccine related research is very important for its control and prevention.
