Analysis of adverse reaction induced by articaine hydrochloride and epinephrine tartrate injection in 75 cases
10.3760/cma.j.issn.1002-0098.2018.02.007
- VernacularTitle: 75例阿替卡因肾上腺素注射液不良反应分析
- Author:
Lijie REN
1
;
Xinyi SONG
2
;
Jiesen SUN
1
;
Xiuqing SUN
1
Author Information
1. Department of Pharmacy, Yantai Stomatological Hospital Affiliated to Binzhou Medical College, Yantai Shandong 264000, China
2. School of Pharmacy in Yantai University, Yantai Shandong 264000, China
- Publication Type:Journal Article
- Keywords:
Anesthetics, local;
Drug monitoring;
Articaine;
Adverse drug reaction
- From:
Chinese Journal of Stomatology
2018;53(2):107-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the causes and clinical manifestation of adverse reaction of articaine hydrochloride and epinephrine tartrate injection.
Methods:A retrospective analysis was conducted on the adverse drug reactions (ADR) of local anesthetic articaine hydrochloride and epinephrine tartrate injection.
Results:In 75 cases of adverse reactions, there were 40 cases of female and 35 cases of male. Adverse reactions occured more frequently at the age of 3-10 [33% (25/75)] and 1-10 min and one day after injection, respectively accounting for 20% (15/75), and two days, accounting for 15% (15/75), 10-21 days accounting for 8% (6/75). The main manifestations were injection site ulcers, followed by skin reactions such as pain, swelling, necrosis and pruritus at the injection site.
Conclusions:The main adverse reactions of articaine hydrochloride and epinephrine tartrate injection are the injection site ulceration, followed by injection site pain, rash, pruritus and drowsiness, nausea and dizziness, palpitations, sweat and hypotension. Doctors should ask the medical history in detail and pay close attention to the patient's medication safety.
