Development and features of infection in patients with acute-on-chronic liver failure and its influence on disease progression and prognosis
10.3760/cma.j.issn.1007-3418.2018.01.003
- VernacularTitle: 慢加急性肝衰竭患者的感染问题：发生、特征及其对疾病进展和预后的影响
- Author:
Zhujun CAO
1
;
Qing XIE
Author Information
1. Shanghai Jiaotong University School of Medicine, Ruijin Hospital, Shanghai 200025, China
- Publication Type:Editorial
- Keywords:
Acute-on-chronic liver failure;
Bacterial infection;
Mechanism;
Prognosis;
Treatment
- From:
Chinese Journal of Hepatology
2018;26(1):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of chronic liver disease associating with multiple organ failures and high short- term mortality. Patients with ACLF are highly susceptible to infection due to the pathophysiology features including immune function disorder (overlap of excessive inflammatory reaction and immune dysfunction), gut bacterial overgrowth/dysbiosis and translocation of gut microbiota/products. Appropriate empirical antibiotics plays a pivotal role in the management of ACLF with infection.
