The significance of circulating tumor cells in head and neck squamous cell carcinoma: a preliminary study
10.3760/cma.j.issn.1673-0860.2018.01.008
- VernacularTitle: 循环肿瘤细胞在头颈部鳞状细胞癌中意义的初步研究
- Author:
Haidong ZHANG
1
;
Shanchun GONG
1
;
Yaqun LIU
1
;
Longjun LIANG
1
;
Shuangba HE
1
;
Qingxiang ZHANG
1
;
Mingyuan SI
1
;
Zhenkun YU
1
Author Information
1. Department of Otorhinolaryngology and Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211100, China
- Publication Type:Journal Article
- Keywords:
Neoplastic cells, circulating;
Head and neck neoplasms;
Carcinoma, squamous cell;
Receptor, Epidermal growth factor;
Mutation
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2018;53(1):39-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the significance of circulating tumor cells (CTC) in squamous cell carcinoma of the head and neck (HNSCC).
Methods:Twenty-four patients with HNSCC treated between October 2016 and July 2017 in our department were selected (experimental group), including 23 males and 1 females, aged 47-81 years. There were 14 cases of squamous cell carcinoma of larynx and 10 cases of hypopharynx, including I-Ⅱ stage (5 cases) and Ⅲ- Ⅳ stage (19 cases). All patients were primary and/or relapsed after treatment. Nine healthy volunteers were selected as control group. A novel in vivo capture technique (CellCellector system) was used to detect CTC. SPSS23.0 was used for statistical analysis.
Results:The total capture rate of CTC in patients with HNSCC before treatment was 70.8% (17/24), with 40% (2/5) for patients at I-Ⅱ stage, and 78.9% (15/19) for patients at Ⅲ- Ⅳ stage, and was 0 in patients of control group. The total capture rate of CTC in patients with HNSCC after treatment was 50% (8/16). There was no significant correlation between CTC and age, sex, location of tumor or lymph node metastasis (P>0.05). CTC was related to tumor staging and tumor differentiation (P<0.05). The positive rate of EGFRVⅢ in CTC was 26.3% (5/19).
Conclusions:The CellCollector system is a very efficient way of detecting CTC, and CTC plays an important role in the occurrence, progression and metastasis of HNSCC.
