Research progress in chronic active Epstein-Barr virus infection
10.3760/cma.j.issn.1003-9279.2018.01.022
- VernacularTitle: 慢性活动性EB病毒感染的研究进展
- Author:
Shufeng TIAN
1
;
Kunling SHEN
2
;
Jikui DENG
1
Author Information
1. Department of Infectious Disease, Shenzhen Children’s Hospital, Shenzhen 518038, China
2. Department of Respiratory Medcine, Beijing Children’s Hospital, Capital Medical University, National Clinical Medical Research Center for Respiratory Diseases, Beijing 100045, China
- Publication Type:Review
- Keywords:
Chronic Active EBV Infection (CAEBV);
EBV-associated lymphoid tissue proliferative diseases;
Hematopoietic stem cell transplantation
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(1):103-107
- CountryChina
- Language:Chinese
-
Abstract:
Chronic active EBV (CAEBV) infection presents with persistent or recurring IM-like symptoms including fever, hepatosplenomegaly, lymphadenopathy, and liver dysfunction without definite underlying diseases at the diagnosis. No causative pathogenetic mechanisms have been sufficiently clarified, these patients have high EBV-DNA load in the peripheral blood and systemic clonal expansion of EBV-infected T cells, NK cells and B cells. Their prognosis is poor with life-threatening complications including hemophagocytic lymphohistiocytosis, diverse organ failure, malignant lymphomas and so on. Allogeneic hematopoietic stem cell transplantation(Allo-HSCT)is the only effective therapy at present. This review outlines the recent progress of CAEBV clinical and fundamental research at home and abroad.
