Progress in studies on mechanism of immune evasion of Epstein-Barr virus
10.3760/cma.j.issn.1003-9279.2018.01.021
- VernacularTitle: EB病毒免疫逃避机制研究进展
- Author:
Junhong AI
1
;
Zhengde XIE
Author Information
1. Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
- Publication Type:Review
- Keywords:
Epstein-Barr virus;
Immune evasion;
Lytic infection;
Latent infection
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(1):98-102
- CountryChina
- Language:Chinese
-
Abstract:
Epstein-Bar virus (EBV) infection is widespread within the human population with over 95% of adults being infected. In response to primary EBV infection, the host mounts an antiviral immune response comprising both innate and adaptive immune system. In healthy populations, the immune system can control EBV infection to a large extent. However, the virus cannot be cleared. Instead, EBV establishes a persistent latent infection in B lymphocytes characterized by limited viral gene expression. To establish a persistent infection efficiently, EBV have evolved a number of strategies to avoid immune elimination. In this review, we focus on the immune evasion mechanisms of EBV encoded immune-evasion proteins, microRNA and host exosome pathway.
