Role of Th1/Th2/Th17 cytokines in maintaining virological response after entecavir discontinuation in patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2018.01.009
- VernacularTitle: Th1/Th2/Th17细胞因子在慢性乙型肝炎患者恩替卡韦停药后维持病毒学应答中的作用
- Author:
Yuanwang QIU
1
;
Jianhe GAN
2
;
Wenlong YANG
1
,
3
;
Yaping DAI
1
;
Jun WANG
1
;
Bo ZHANG
1
;
Zhen WANG
1
;
Tingting SU
1
;
Yiguang LI
1
;
Hongyan ZHOU
1
;
Wei XU
1
;
Lihua HUANG
1
Author Information
1. The Fifth People’s Hospital of Wuxi, Wuxi 214005, China
2. The First Affiliated Hospital of Suzhou University, Suzhou 215006, China
3. The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
- Publication Type:Journal Article
- Keywords:
Cytokines;
Hepatitis B, chronic;
Entecavir;
Recurrence
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(1):43-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics underlying Th1/Th2/Th17 expression level after entecavir (ETV) discontinuation of chronic hepatitis B (CHB) patients who were HBeAg-positive and define the role of Th1/Th2/Th17 in maintaining virological response after ETV discontinuation.
Methods:We selected 112 HBeAg positive CHB patients who met the withdrawal criteria according to the guideline of prevention and treatment of chronic hepatitis B (2010 version), and we also separated them into virology sustained response (SVR) group and virological relapse (VR) group according to the recurrence in 52 weeks. We detected serum level of Th1/Th2/h17 related cytokines during 0, 12, 24 and 52 weeks follow-up to further analyze their dynamic changes and expression differences.
Results:The results of the study reveals that serum levels of IFN-γ in the group of SVR were at a higher level compared with VR group during follow-up (all P<0.05). While, the serum level of IL-10 decreased in SVR group and was lower than the paired IL-10 level in VR group with significance during follow-up. In VR group, the serum level of IFN-γ decreased during the first 24 weeks after ETV withdrawal, and after then, the level rose. The serum levels of IFN-γ (Th1) in SVR patients were significantly higher than those in VR patients in the different follow-up time points after ETV discontinuation (all P<0.05). And the serum levels of IL-10 (Th2) in SVR patients were significantly lower than that in VR patients (all P<0.05). The comparison of serum levels of IL-17A (Th17) between the two groups had no significant difference (all P>0.005).
Conclusions:The serum level of IFN-γ in SVR group maintained a high level is conducive to maintaining virological response after ETV withdrawal and high level of IL-10 may be related to virologic relapse.
