Research progress in the function of monocyte/macrophage-lineage origin cells in the peri-implant osseointegration interface
10.3760/cma.j.issn.1002-0098.2018.01.014
- VernacularTitle: 单核巨噬细胞系统来源细胞在种植体骨结合中功能的研究进展
- Author:
Juan ZHAO
1
;
Xu HUANG
2
Author Information
1. Department of Prosthodontics, Affiliated Hospital of Stomatology, Zhejiang University School of Medicine, Hangzhou 310006, China
2. Department of Stomatology, The Affiliated First Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
- Publication Type:Review
- Keywords:
Mononuclear phagocyte system;
Osteoclasts;
Synostosis;
Multinucleated giant cells;
Inflammatory immune reaction
- From:Chinese Journal of Stomatology
2018;53(1):66-70
- CountryChina
- Language:Chinese
-
Abstract:
Although many studies have focused on how material surface modifications can promote stem cell differentiation toward osteogenic osteoblasts, little is known about the reaction between material surface and other cells, including osteoclasts and foreign body giant cells. Dental implant osseointegration results from the functional coupling and equilibrium not only between osteoblasts and osteoclasts but also between bone tissue and immune system. Osteoclasts and foreign body giant cells share the same origin, monocyte/macrophage lineage cells, which have initially got concerns in the field of implant osseointegration with regard to their peri-implant distribution and biological functions. Up-to-date data has shown that cells of monocyte/macrophage lineage origin manifest key roles in the establishment of peri-implant osseointegration and the long-term maintenance of marginal bone level and the prevalence of peri-implantitis. However, preliminary progress has been made in the subtypes, phenotypes vs. genotypes, and functions of monocyte/macrophage-lineage-originated cells on the osseointegration interface, quite a lot of facts still remain unclear, especially the potential and the rapeutic targets which could coordinate the cellular peri-implant microenvironment and the implant osseointegrated interface in the short and long term. This review will focus on the current progress in the function of monocyte/macrophage-lineage origin cells on the peri-implant osseointegration interface.
