Research progress of salivary glands mucosa-associated lymphoid tissue lymphoma
10.3760/cma.j.issn.1002-0098.2018.01.012
- VernacularTitle: 唾液腺黏膜相关淋巴组织淋巴瘤的研究进展
- Author:
Qian SU
1
;
Guangyan YU
1
Author Information
1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
- Publication Type:Review
- Keywords:
Salivary gland mucosa-associated lymphoid tissue lymphoma;
Mucosa-associated lymphoid tissue lymphoma;
Salivary gland neoplasms
- From:
Chinese Journal of Stomatology
2018;53(1):54-59
- CountryChina
- Language:Chinese
-
Abstract:
Salivary glands mucosa-associated lymphoid tissue lymphoma (SGML) is a distinct subtype of marginal zone B-cell type non-Hodgkin′s lymphoma (NHL), which is commonly seen in middle aged females. SGML is usually associated with autoimmune diseases such as Sjögren's syndrome or with chronic infection such as hepatitis C virus (HCV) infection. Chromosomal abnormalities are frequently seen in SGML, which usually activate nuclear factor-κB molecular pathway to modulate cell survival and proliferation, resulting in lymphoma occurrence. SGML tends to arise from parotid gland, presenting frequently as a localized and indolent lesion, a long-term follow-up and biopsy are needed for accurate diagnosis. Surgery, radiotherapy and chemotherapy are usually effective disseminated diseases at multiple sites need combined treatment. SGML has a relatively better prognosis with a higher relapse rate than other types of NHLs, dissemination or higher degree of malignant transformation may occur. Thus, a long-term and close follow-up is essential for patients with SGML.
