Preparation, in vitro imaging and antitumor activity of the second near-infrared imaging drug-loaded liposomes
10.11665/j.issn.1000-5048.20190408
- VernacularTitle:近红外二区成像载药脂质体的制备、体外成像及抗肿瘤活性
- Author:
Zian WANG
1
;
Yang LIU
;
Peng WANG
;
Yifei JIANG
;
Min JI
Author Information
1. 东南大学生物科学与医学工程学院
- Publication Type:Journal Article
- Keywords:
NIR-II imaging;
doxorubicin;
theranostics;
cationic liposome;
antitumor activity
- From:
Journal of China Pharmaceutical University
2019;50(4):438-443
- CountryChina
- Language:Chinese
-
Abstract:
The combination of diagnosis and treatment through nanotechnology is conducive to the development of cancer treatment. Fluorescent imaging in the second near-infrared window(NIR-II)developed rapidly in recent years due to its imaging advantages. In this paper, we prepared a novel nano drug system, DOX-IR1061-cationic liposome, in which NIR-II fluorescent probe IR1061 was loaded as imaging agents and doxorubicin was loaded as therapeutic agents. It also explores enhanced cellular uptake and cancer cell inhibition rate through octadecylamine. Our NIR-II performance test on liposomes showed that DOX-IR1061-cationic liposome has NIR-II imaging ability. Analysis of liposome cell uptake behavior and cancer cell inhibition experiments demonstrated that octadecylamine can promote liposome uptake by cells and synergize with DOX to enhance anticancer effects. This suggests that the DOX-IR1061-cationic liposome can be used to achieve imaging and therapy effect with further research value.
