Surface solid dispersion of honokiol-croscarmellose sodium:preparation and characterization
10.11665/j.issn.1000-5048.20190406
- VernacularTitle:和厚朴酚-交联羧甲基纤维素钠表面固体分散体的制备及表征
- Author:
Wujun DONG
1
;
Qiang FU
;
Huixia LYU
Author Information
1. 中国药科大学药学院；中国医学科学院药物研究所
- Publication Type:Journal Article
- Keywords:
honokiol;
croscarmellose sodium;
surface solid dispersion;
dissolution;
melting method
- From:
Journal of China Pharmaceutical University
2019;50(4):417-422
- CountryChina
- Language:Chinese
-
Abstract:
The surface solid dispersion of honokiol was prepared by melting method with croscarmellose sodium as carrier to improve the dissolution rate of honokiol, taking the advantage of its low melting point. The dissolution rate and stability test of surface solid dispersion of honokiol were carried out. Its physical properties were then investigated by DSC, PXRD and SEM analysis. The results indicated that the dissolution rate of honokiol from sodium solid dispersion was more than 90% at 15 min while its mean dissolution time was significantly decreased. Honokiol was distributed on the surface of croscarmellose sodium in the form of microcrystal; moreover, its dissolution behavior didn′t change significantly after six months of stability tests. Therefore, surface solid dispersion of honokionl could be prepared by simple process. The formed solid dispersion achieved high drug loading and fast in vitro dissolution rate, which could provide a novel idea for developing solid preparations of honokiol.
