Research progress and consideration of polymeric prodrugs
10.11665/j.issn.1000-5048.20190403
- VernacularTitle:高分子前药的研究进展
- Author:
Tianjiao HAN
1
;
Yuxi HU
;
Hongzheng FU
Author Information
1. 北京大学药学院 天然药物及仿生药物国家重点实验室
- Publication Type:Journal Article
- Keywords:
polymeric prodrugs;
passive targeting;
active targeting;
triggered release;
co-administration
- From:
Journal of China Pharmaceutical University
2019;50(4):397-404
- CountryChina
- Language:Chinese
-
Abstract:
Currently the available therapies cannot satisfy all the clinical requirements, therefore advanced technologies are urgently demanded. Delivery system the polymeric prodrug based has both advantages of prodrug strategy and nanoparticle drug delivery strategy. The system can improve the drug bioavailability, enhance the drug stability, and make the drug targeting system more effective. The system can reduce the side effects and improve the therapeutic effect of drug. According to the mechanism of this drug system, passive targeting, active targeting, triggered release and co-administration were reviewed. Finally, the research prospects and issues in this field were pointed out.
