Research progress of synthetic methods of ［18F］F-DOPA
10.11665/j.issn.1000-5048.20190313
- VernacularTitle:［18F］F-DOPA合成方法的研究进展
- Author:
Weihua CHENG
1
;
Feihu GUO
;
Xuesong DENG
;
Xiangyu QIN
;
Hongqiang FAN
;
Ji HU
Author Information
1. 原子高科股份有限公司
- Publication Type:Journal Article
- Keywords:
［18F］6-fluoro-3,4-dihydroxy-L-phenylalanine;
nucleophilic substitution;
fluorination;
radiochemical synthesis
- From:
Journal of China Pharmaceutical University
2019;50(3):357-363
- CountryChina
- Language:Chinese
-
Abstract:
［18F］6-fluoro-3, 4-dihydroxy-L-phenylalanine(［18F］F-DOPA)has been used as a radiotracer for Parkinson′s disease over 30 years. The previously reported electrophilic synthesis method has low radiochemical yield(RCY), low specific activity(SA)and other defects. Recent reported nucleophilic synthesis of ［18F］F-DOPA could overcome the disadvantages. In this paper, the nucleophilic synthetic methods for ［18F］F-DOPA are reviewed.
