Regulation of mTOR singnaling pathway by microRNA in hepatocellular carcinoma
10.3760/cma.j.issn.1673-422X.2019.10.012
- VernacularTitle: 肝细胞癌中微小RNA对mTOR信号通路的调控作用
- Author:
Yaqian NIU
1
;
Yuling CHANG
1
;
Fang LIU
1
;
Huiyuan CHU
1
;
Che CHEN
1
Author Information
1. College of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China
- Publication Type:Review
- Keywords:
Carcinoma, hepatocellular;
MicroRNAs;
TOR serine-threonine kinases
- From:
Journal of International Oncology
2019;46(10):624-626
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) is a non-coding small molecule RNA, which is involved in the occu-rrence and development of tumor as an oncogene or tumor suppressor gene. The abnormal expression of many kinds of miRNAs in hepatocellular carcinoma (HCC) can directly or indirectly act on PI3K, Akt, mTOR, IGF-1R, TGF-β and other signal molecules in mTOR signal pathway, they are crucial in the appreciation, invasion and metastasis of HCC cells.
