lncRNA and small cell lung cancer

VernacularTitle: lncRNA与小细胞肺癌
Author: Chao MING ¹ ; Rui HE ¹ ; Yuan SUN ¹ ; Linghan TIAN ² ; Guangqiang ZHAO ¹
Author Information

1. First Department of Thoracic Surgery, Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650100, China
2. Cancer Research Institute, Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming 650100, China
Publication Type:Review
Keywords: Small cell lung carcinoma; RNA, long noncoding
From: Journal of International Oncology 2019;46(10):620-623
CountryChina
Language:Chinese
Abstract: The incidence and mortality of lung cancer rank first, and small cell lung cancer (SCLC) accounts for about 15% of lung cancer cases. In recent years, it has been found that long non-coding RNA (lncRNA) (TUG1, CCAT2, PVT1, HOTTIP and HOTAIR) plays a significant role in the development of SCLC. lncRNA can regulate the expression of related genes at the transcriptional, posttranscriptional and epigenetic levels, and it can infulence proliferation, invasion, metastasis and chemotherapy resistance of SCLC.