Transforming growth factor-β signaling pathway and targeted therapy in ovarian cancer
10.3760/cma.j.issn.1673-422X.2019.09.011
- VernacularTitle: 转化生长因子-β通路与卵巢癌靶向治疗
- Author:
Nanmin TANG
1
;
Zhancai YU
2
Author Information
1. Department of Gynaecology and Obstetrics, People′s Hospital of Longchang City, Sichuan Province, Longchang 642150, China
2. Department of Oncology, Weihai Municipal Hospital, Shandong Province, Weihai 264200, China
- Publication Type:Review
- Keywords:
Ovarian neoplasms;
Transforming growth factor β
;
Molecular targeted therapy
- From:
Journal of International Oncology
2019;46(9):562-565
- CountryChina
- Language:Chinese
-
Abstract:
The transforming growth factor-β (TGF-β) is a polypeptide cytokine, belonging to the TGF-β superfamily. TGF-β signaling pathway can regulate cell biological activity and play a bidirectional regulatory role in the development and progression of cancer. TGF-β signaling pathway can cause the occurrence and development of ovarian cancer through various processes including inducing cell excessive proliferation, influencing tumor microenvironment and regulating immune evasion. Targeted therapy with TGF-β as a biomar-ker for ovarian cancer provides a new way to improve the prognosis of patients.
